姓名：李广迪
职称：教授，博士生导师，硕士生导师
学位：生物医学博士，计算机硕士，数学本科
党派：中国致公党党员，致公党湘雅医院总支委员,湖南省致公党省委医专委秘书长
电话：0731-84805414
邮箱：liguangdi@csu.edu.cn, 550604042@qq.com
部门：BETVLCTOR伟德官方网站，bevictor伟德
入选：湖南省 “杰青”，湖南省 “湖湘青年英才”、湖南省 “归国华侨”、湖南省 “50名优秀海归党员”、湖南省 “抗击新冠肺炎疫情先进个人”
研究方向：我们团队以病毒流行病学，计算机学，生物化学和生物医学多交叉学科为背景，结合临床实际问题，致力于生物信息学新算法和软件的开发，潜心研究病毒基因组学和抗病毒药物，形成了完善的知识体系，并组建了成熟的科研团队。
一、个人学习经历
2009/09 — 2014/08，比利时鲁汶大学(2024泰晤士全球大学排名45位),医学院,生物医学博士
2010/09 — 2011/07，比利时鲁汶大学,生命科学院，化学与生物物理学进修硕士
2006/09 — 2009/06，山东大学，计算机科学与技术学院，计算机软件与理论硕士
2002/09 — 2006/06，湖南大学，数学与计量经济学院，数学与应用数学本科
1996/09 — 2002/06，湖南师大附中，初中和高中
二、个人工作经历
2023/10 — 至 今, 教 授，博士生导师，研究生导师，bevictor伟德
2018/04 — 2023/09, 副教授，博士生导师，研究生导师，bevictor伟德
2015/01 — 2018/02，副教授，研究生导师，BETVLCTOR伟德官方网站湘雅二医院，
2008/03 — 2009/08，研究助理，西班牙马德里理工大学UPM（西班牙重点公立大学）计算机学院，获UPM研究生全额奖学金
三、人才计划和获奖情况
2024年，湖南省“杰青”
2023年，第十八届“挑战杯”全国老员工课外学术科技作品竞赛，全国二等奖，第一指导老师
2023年，致公党湖南省委“50名优秀海归党员”
2023年，BETVLCTOR伟德官方网站“优秀班导师”
2022年，BETVLCTOR伟德官方网站“优秀本科生毕业论文指导老师”
2020年，抗击新冠肺炎疫情“先进个人”（致公党湖南省委会）
2018年，湖南省“湖湘青年英才”
2017年，BETVLCTOR伟德官方网站科研成果专项奖
2008年，第五届中国研究生数学建模竞赛，全国一等奖
四、科研基金项目
个人主持 9 个科研项目（4个国家级项目，3个省级项目，2个校级项目），及参与2个科研项目。
1. 主持人，湖南省杰青项目，人类病毒的分子流行病学和生物信息学研究，50万，2024/05 - 2027/05
2. 主持人，国家自然科学基金 - 重大研究计划（批准号：92269112），基于生物信息学的新冠蛋白-宿主免疫蛋白动态调控网络及其广谱性药物靶点研究，70万，2023/01 - 2025/12
3. 主持人，国家自然科学基金 - 面上项目（批准号：31871324），HIV全基因组共进化诱导药物耐药性的生物信息学研究，60万，2019/01–2022/12
4. 主持人，国家自然科学基金 - 面上项目（批准号：31571368），基于系统生物学的HIV全基因组蛋白交互机制研究，57万，2016/01–2019/12
5. 子课题主持人，国家自然科学基金 - 重点项目（批准号：81730064），丙型肝炎病毒逃逸人肝细胞先天免疫应答而致持续感染机制，30万，2018/01–2022/12
6. 主持人，湖南省自然科学基金 - 青年项目（批准号：2018JJ3713），HIV Gag基因突变诱导蛋白酶抑制剂抗药性的系统生物学研究，5万，2018/01–2020/12
7. 主持人，湖南省湖湘青年英才基金（批准号：2018RS3006），50万，2019/01–2021/12
8. 主持人，BETVLCTOR伟德官方网站人才引进基金资助项目，80万，2019/01–2021/12
9. 主持人，BETVLCTOR伟德官方网站“创新驱动计划”人才基金（批准号：2016CX031），60万，2016/01–2017/12
10. 课题骨干，中国科学技术部国家重点研发计划（项目批准号：2016YFC1305001），1型糖尿病的遗传与免疫学发病机制研究，700万，2016/10 – 2021/10
11. 课题骨干，湖南省科技厅-芙蓉实验室科技攻关项目（批准号：2023SK2090），重大传染病预测预警模型及平台建立，50万，2023/09 – 2025/09
五、公司产品改革研究课题
1. 主持人，湖南省普通本科高校教学改革研究项目，在线统计软件 + 线下案例教学的本科生 《医学统计学B》混合式课程建设和实践，2024/03 - 2026/03
2. 主持人，BETVLCTOR伟德官方网站研究生院，基于“在线软件+案例库”的研究生《医学统计学》“线上线下”双轨教学案例库建设，批准号：2024ALK019，2024/05 - 2026/05
3. 主持人，BETVLCTOR伟德官方网站研究生院，职工《Medical Statistics》的课程思政建设，2023/05 - 2025/05
六、SCI期刊论文
病毒流行病和病毒生物信息学领域，共计发表50余篇SCI论文，其中第一或通讯作者论文>30篇（影响因子合计>400，引用>5000次数）
Guangdi Li*, Rolf Hilgenfeld*, Richard Whitley*, Erik De Clercq*, Therapeutic strategies for COVID-19: progress and lessons learned, Nature Reviews Drug Discovery, 2023 Jun;22(6):449-475 (第一作者/共同通讯作者，影响因子：120.1，JCR一区)
Yujin Ding, Pan Zhang, Tuo Deng, Xiang Yan, Min Zhang, Zhiguo Xie, Gan Huang, Ping Wang, Ting Cai, Xiaoli Zhang, Xinqiang Xiao, Ying Xia, Bingwen Liu, Ya Peng, Xiaohan Tang, Ming Hu, Yang Xiao, Xia Li, Erik De Clercq, Guangdi Li*, Zhiguang Zhou*, Association of HLA footprints with the comorbidity of latent autoimmune diabetes in adults (LADA) and HCV infection: A Multicenter Cross-Sectional Study, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2024 January; 18(1):102939 (共同通讯作者，影响因子：10.1)
Pan Zhang, Xiaowen Hu, Guangdi Li*, Lei Deng*, AntiViralDL: Computational Antiviral Drug Repurposing Using Graph Neural Network and Self-Supervised Learning, IEEE Journal of Biomedical and Health Informatics, 2023, DOI: 10.1109/JBHI.2023.3328337 (共同通讯作者，影响因子：7.7，JCR一区)
Erik De Clercq#, Zhenlan Zhang#, Jie Huang, Min Zhang*, Guangdi Li*, Biktarvy for the treatment of HIV infection: Progress and prospects, Biochemical Pharmacology. 2023 Nov:217:115862 (最后通讯作者，影响因子：5.8，JCR一区)
Ting Cai, Tingting Yue, Ming Xu, Pan Zhang, Yue Wang, Qi Liu, Jie Huang, Ting Shen, Qiang Yin, Zhifeng Sheng, Yang Xiao, Tuo Deng, Min Zhang, Erik De Clercq, Chi Zhang*, Guangdi Li*, Poor glycemic control in type-2 diabetic patients infected with hepatitis B: a retrospective propensity-matched study, Journal of Medical Virology, 2023, Mar;95(3):e28635 (最后通讯作者，影响因子：12.7，JCR一区)
Ming Xu, Ting Cai, Tingting Yue, Pan Zhang, Jie Huang, Qi Liu, Yue Wang, Ruping Luo, Zhengqiu Li, Linli Luo, Chunyi Ji, Xinrui Tan, Yanling Zheng, Richard Whitley, Erik De Clercq, Qiang Yin*, Guangdi Li*, Comparative Effectiveness of Oseltamivir versus Peramivir for Hospitalized Children (ages 0–5 years) with Influenza Infection, International Journal of Infectious Diseases, 2023 Mar;128:157-165 (最后通讯作者，影响因子：8.4，JCR一区)
Chen Jia#, Zhiguo Zhou#, Song Li#, Pan Zhang#, Wenjing Pan, Ming Yang, Mingming Zhao, Bo Li, Ping Liu, Qianqian Zhang, Xianglong Kong, Keyu Li, Zijun Wang, Tingting Yue, Ting Cai, Erik De Clercq, Song Li*, Guangdi Li*, Jiyang Liu*, Haijing Wu*, Qianjin Lu*，Immune Repertoire Sequencing Reveals an Abnormal Adaptive Immune System in COVID-19 Survivors，Journal of Medical Virology, 2023 Jan;95(1):e28340 (共同通讯作者，影响因子：12.7，JCR一区)
Erik De Clercq, Yike Jiang, Guangdi Li*, Therapeutic strategies for human poxvirus infections: monkeypox (mpox), smallpox, molluscipox, and orf,Travel Medicine and Infectious Disease, 2022，52:102528（唯一通讯作者，影响因子：12.0，JCR一区）
Guangdi Li, Yali Wang*, Erik De Clercq*, Approved HIV reverse transcriptase inhibitors in the past decade, Acta Pharmaceutica Sinica B, 2022 Apr;12(4):1567-1590 (第一作者，影响因子：14.5，JCR一区)
Guangdi Li, Erik De Clercq*, A medicinal chemist who reshaped the antiviral drug industry , Medicinal Research Reviews,2022 Mar;42(2):647-653(第一作者，影响因子：13.3，JCR一区)
Tingting Yue, Quanquan Zhang, Ting Cai, Ming Xu, Haizhen Zhu, Mahmoud Reza Pourkarim, Erik De Clercq, Guangdi Li*,Trends in the disease burden of HBV and HCV infection in China from 1990-2019, International journal of infectious diseases, 2022 Jun 17;122:476-485. (唯一通讯作者，影响因子：8.4，JCR一区)
Xixi Jing #, Min Xu #, Deye Song#, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq Guangdi Li*, Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19, Immunity & Ageing, 2022 Mar 5;19(1):12（唯一通讯作者，JCR一区，影响因子: 7.9，JCR一区）
Tingting Yue, Ming Xu, Ting Cai, Haizhen Zhu, Mahmoud Reza Pourkarim, Erik De Clercq, Guangdi Li*， Gender disparity and temporal trend of liver cancer in China from 1990 to 2019 and predictions in a 25-year period, Frontiers in Public Health，2022 Jun 9;10:902537 (唯一通讯作者，影响因子：5.2，JCR一区)
Tingting Yue, Pan Zhang, Yuantao Hao, Jianmei He, Jun Zheng, Erik De Clercq, Guangdi Li*, Yaxiong Huang*, Fang Zheng*, Epidemiology and Clinical Outcomes of HIV Infection in South-Central China: A Retrospective Study From 2003 to 2018, Frontiers in Public Health，2022 Jun 9;10:902537 (共同通讯作者，影响因子：5.2，JCR一区)
Tingting Yue#, Quanquan Zhang#, Guangdi Li*, Hong Qin*，Global Burden of Nutritional Deficiencies among Children under 5 Years of Age from 2010 to 2019，Nutrients. 2022 Jun 28;14(13):2685 (共同通讯作者，影响因子：5.9，JCR一区)
Miao Miao, Erik De Clercq, Guangdi Li*，Towards Efficient and Accurate SARS-CoV-2 Genome Sequence Typing Based on Supervised Learning Approaches, Microorganisms, 2022, 10(9), 1785 (唯一通讯作者，影响因子：4.5，JCR二区)
Miao Miao, Erik De Clercq, Guangdi Li*.Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective, Biomedicines 2021, 9, 412 (唯一通讯作者，影响因子：6.05，JCR一区)
Guangdi Li, Ming Xu, Tingting Yue, Weijie Gu, and Li Tan*, Life-long Passion for Antiviral Research and Teaching: 80th Anniversary of Prof. Dr. Erik De Clercq, Biochemical Pharmacology, 2021 Feb 19;185:114485 (第一作者，影响因子：6.1，JCR一区)
Guangdi Li, Tingting Yue, Pan Zhang, Weijie Gu, Ling-Jie Gao, and Li Tan*, Drug Discovery of Nucleos(t)ide Antiviral Agents, Molecules, 2021 Feb 9;26(4):923 (第一作者，影响因子：4.927，JCR二区)
Guangdi Li*,Erik De Clercq*, Therapeutic options for the 2019 novel coronavirus (2019-nCoV), Nature Reviews Drug Discovery. 2020,March;19(3):149-150（第一作者，影响因子：84.69，引用次数>1000）
Chuanhao Jiang, Yali Wang, Min Hu, Lingjun Wen, Chuan Wen, Yang Wang, Weihong Zhu, Shi Tai, Zhongbiao Jiang, Kui Xiao, Nuno Rodrigues Faria, Erik De Clercq, Junmei Xu, Guangdi Li*. Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical & Translational Immunology.2020 Sep 26;9(9):e1182 (唯一通讯作者，影响因子：6.16)
Guangdi Li,Yacong Liu, Xixi Jing, Yali Wang, Miao Miao, Li Tao, Zhiguo Zhou, Yuanlin Xie, Yaxiong Huang, Jianhua Lei, Guozhong Gong, Ping Jin, Yuantao Hao, Nuno Rodrigues Faria, Erik De Clercq, Min Zhang*. Mortality risk of COVID-19 in elderly males with comorbidities: A multi-country study, Aging. 2020 Dec 31;13(1):27-60 (第一作者，影响因子：5.68，JCR一区)
Zhiguo Zhou†, Min Zhang†, Yali Wang†, Fang Zheng, Yaxiong Huang, Kang Huang, Qizhi Yu, Chunlin Cai, Dong Chen, Yi Tian, Jianhua Lei, Xinqiang Xiao, Erik De Clercq,Guangdi Li*,Yuanlin Xie*, Guozhong Gong*, Clinical characteristics of older and younger patients infected with SARS-CoV-2, Aging. 202012(12):11296-11305 (共同通讯作者，影响因子：5.68，JCR一区)
Miao Miao, Xixi Jing, Erik De Clercq,Guangdi Li*, Danoprevir for the Treatment of Hepatitis C Virus Infection, Drug Design, Development and Therapy, 2020 July:14: 2759-2774 (唯一通讯作者，影响因子：4.16，JCR二区)
Miao Miao, Erik De Clercq,Guangdi Li*, Clinical significance of chemokine receptor antagonists, Expert Opinion on Drug Metabolism & Toxicology, 2020 Jan;16(1):11-30（唯一通讯作者, 影响因子：4.48，JCR二区）
Min Zhang†,Guangdi Li†,Jia Shang, Chen Pan, Minxiang Zhang, Zhibiao Yin 6, Qing Xie, Yanzhong Peng, Qing Mao, Xinqiang Xiao, Yongfang Jiang1, Kaizhong Luo1, Yun Xu, Hai Ding, Wenzhou Fan, Vidaurre Diego, MahmoudReza Pourkarim, Erik De Clercq, Guiqiang Wang*, Guozhong Gong*,Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study, Hepatology International, 2020，14(2):212-2242020 (共同第一作者，影响因子:6.05)
Yali Wang, Erik De Clercq,Guangdi Li*, Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment,Expert Opinion on Drug Metabolism & Toxicology, 15(10):813-829, 2019（唯一通讯作者，影响因子：3.487，JCR二区）
Erik De Clercq,Guangdi Li*，Approved Antiviral Drugs over the Past 50 Years，Clinical Microbiology Reviews. Jul;29(3):695-747, 2016（共同通讯作者，影响因子：19.96， 被评为期刊封面论文，入选前0.1% ESI千分之一热点论文，JCR一区）、
Guangdi Li*, Erik De Clercq*, HIV Genome-Wide Protein Associations: a Review of 30 Years of Research, Microbiology and Molecular Biology Reviews. 80(3):679-731, 2016（第一作者，影响因子14.6，期刊封面，JCR一区）
Guangdi Li*, Erik De Clercq*, Current therapy for chronic hepatitis C: The role of direct-acting antivirals, Antiviral Research. 24;142:83-122, 2017（第一作者，影响因子：4.307，期刊封面论文，入选前1% ESI高频引用论文）
Guangdi Li, Kristof Theys, Jens Verheyen, Andrea-Clemencia Pineda-Peña, Ricardo Khouri, Supinya Piampongsant, Mónica Eusébio, Jan Ramon, Anne-Mieke Vandamme. A new ensemble coevolution system for detecting HIV-1 protein coevolution. Biology Direct, 10:1, 2015 (第一作者，影响因子: 4.04， JCR二区)
Guangdi Li, Supinya Piampongsant, Nuno Rodrigues Faria, Arnout Voet, Andrea-Clemencia Pineda-Peña, Ricardo Khouri, Philippe Lemey, Anne-Mieke Vandamme, Kristof Theys. An integrated map of HIV genome-wide diversity from a population perspective. Retrovirology, 12:18, 2015 (第一作者，影响因子: 3.99， JCR二区)
Guangdi Li, Jens Verheyen, Kristof Theys, Supinya Piampongsant, Kristel Van Laethem, Anne-Mieke Vandamme. HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes. Retrovirology, 11:79, 2014 (第一作者，影响因子: 4.19， JCR一区)
Guangdi Li, Jens Verheyen, Soo-Yon Rhee, Arnout Voet, Anne-Mieke Vandamme, Kristof Theys, Functional conservation of HIV-1 Gag: implications for rational drug design. Retrovirology 10(1):126. 2013 (第一作者，影响因子: 5.66)
Lize Cuypers†,Guangdi Li†, Christoph Neumann-Haefelin, Supinya Piampongsant, Pieter Libin, Kristel Van Laethem, Anne-Mieke Vandamme and Kristof Theys. Mapping the genomic diversity of HCV subtypes 1a and 1b: Implications of structural and immunological constraints for vaccine and drug development. Virus Evolution, 2(2): vew024, 2016 (共同第一，影响因子: 5.4， JCR一区)
Marijn Thijssen, Gholamreza Khamisipour, Mohammad Maleki, Timothy Devos, Guangdi Li, Marc Van Ranst, Jelle Matthijnssens, Mahmoud Reza Pourkarim，Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients. Viruses . 2023 Jun 23;15(7):1425 （合作作者，JCR一区，影响因子：4.7）
Mengmeng Guo, Wenyan Cao, Shengwen Chen, Renyun Tian, Binbin Xue, Luoling Wang, Qian Liu, Rilin Deng, Xintao Wang, Zhenghao Wang, Yingdan Zhang, Di Yang, Chaohui Zuo, Guangdi Li, Songqing Tang, Haizhen Zhu, TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a, Journal of Immunology. 2022 Nov 15;209(10):1987-1998 （合作作者，JCR一区，影响因子：5.426）
Haijing Wu, Yaxiong Deng, Di Long, Ming Yang, Qianwen Li, Yu Feng, Yongjian Chen, Hong Qiu, Xin Huang, Zhenghao He, Longyuan Hu, Heng Yin, Guangdi Li, Yunkai Guo, Wenhan Du, Ming Zhao, Liwei Lu, Qianjin Lu, The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease, Clinical And Translational Medicine. 2022 Mar;12(3):e781（合作作者，JCR一区，影响因子：8.554）
Xiaozhou Li#, Jian Pan#, Huiling Li, Guangdi Li, Bohao Liu, Xianming Tang, Xiangfeng Liu, Zhibiao He, Zhenyu Peng, Hongliang Zhang, Luxiang Wang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Dongshan Zhang*，DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease，EBioMedicine . 2022 Feb 3;76:103859（合作作者，JCR一区，影响因子：8.14）
Yujin Ding, Guangdi Li, Zhiguang Zhou, Tuo Deng, Molecular mechanisms underlying hepatitis C virus infection-related diabetes, Metabolism-Clinical and Experimental. 2021 Aug;121:154802（合作作者，JCR一区，影响因子：13.934）
William Marciel de Souza, Lewis Fletcher Buss, Darlan da Silva Candido, Jean-Paul Carrera, Sabrina Li, Alexander E. Zarebski, Rafael Henrique Moraes Pereira, Carlos A. Prete Jr, Andreza Aruska de Souza-Santos, Kris V. Parag, Maria Carolina T. D. Belotti, Maria F. Vincenti-Gonzalez, Janey Messina, Flavia Cristina da Silva Sales, Pamela dos Santos Andrade, Vítor Heloiz Nascimento, Fabio Ghilardi, Leandro Abade, Bernardo Gutierrez, Moritz U. G. Kraemer, Carlos K. V. Braga, Renato Santana Aguiar, Neal Alexander, Philippe Mayaud, Oliver J. Brady, Izabel Marcilio, Nelson Gouveia, Guangdi Li, Adriana Tami, Silvano Barbosa de Oliveira, Victor Bertollo Gomes Porto , Fabiana Ganem, Walquiria Aparecida Ferreira de Almeida, Francieli Fontana Sutile Tardetti Fantinato, Eduardo Marques Macário, Wanderson Kleber de Oliveira, Mauricio L. Nogueira, Oliver G. Pybus, Chieh-Hsi Wu, Julio Croda, Ester C. Sabino, and Nuno Rodrigues Faria. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. Nature Human Behaviour. 2020 Aug;4(8):856-65. PMID: 32737472. doi: 10.1038/s41562-020-0928-4. (合作作者，影响因子：24.25， JCR一区)
Xiaozhou Li, Jian Pan, Huiling Li, Guangdi Li, Xiangfeng Liu, Bohao Liu, Zhibiao He, Zhengyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Feng Liu, Dongshan Zhang. DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice. Nature Communications. 2020 Sep 18;11(1):4467 (合作作者，影响因子：12.121， JCR一区)
Sai-Qun Luo, De-Hui Xiong, Jiang Li, Guangdi Li, Yali Wang, Jia-Ming Zhang, Xiu-Fen Bu, Wei-Xin Hu, Jingping Hu, C1orf35 contributes to tumorigenesis by activating c-MYC transcription in multiple myeloma. Oncogene. 2020 Apr;39(16):3354-66. (合作作者，影响因子：7.971， JCR一区)
Rilin Deng, Chaohui Zuo, Yongqi Li, Binbin Xue, Zhen Xun, Yanxia Guo, Xiaohong Wang, Yan Xu, Renyun Tian, Shengwen Chen, Qian Liu, Jinwen Chen, Jingjing Wang, Xiang Huang, Huiyi Li, Mengmeng Guo, Xintao Wang, Miaomiao Yang, Zhihui Wu, Jinfeng Wang, Jiahuan Ma, Jun Hu,Guangdi Li, Songqing Tang, Zhengkun Tu, Hongbin Ji, and Haizhen Zhu, The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 2020 Nov;17(11):1163-1179 (合作作者，影响因子：22.1， JCR一区)
Qian Li, Yifan Wang, Weijuan Jia, Heran Deng, Guangdi Li, Weiye Deng, Jiewen Chen, Betty Y S Kim, Wen Jiang, Qiang Liu, Jieqiong Liu, Low-Dose Anti-Angiogenic Therapy Sensitizes Breast Cancer to PD-1 Blockade. Clin Cancer Res. 2020 Apr 1;26(7):1712-24. (合作作者，影响因子：10.107， JCR一区)
Qinya Xie, Shengwen Chen, Renyun Tian, Xiang Huang, Rilin Deng, Binbin Xue, Yuwen Qin, Yan Xu, Jingjing Wang, Mengmeng Guo, Jinwen Chen, Songqing Tang, Guangdi Li, Haizhen Zhu, Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5, Journal of Virology, 2018 Aug 16;92(17). pii: e00507-18 (合作作者，影响因子：4.368，JCR一区)
Binbin Xue, Huiyi Li, Mengmeng Guo, Jingjing Wang, Yan Xu, Xuan Zou, Rilin Deng, Darong Yang, Guangdi Li, Haizhen Zhu. TRIM21 promotes innate immune response through Lys27-linked poly-ubiquitination of MAVS, Journal of Virology, 2018 Jun 29;92(14):e00321-18 (合作作者，影响因子：4.368， JCR一区)
Yuwen Qin, Binbin Xue, Chunyan liu, Xiaohong Wang, Renyun Tian, Qinya Xie, Mengmeng Guo, Guangdi Li, Darong Yang, and Haizhen Zhu.NLRX1 mediates MAVS degradation to attenuate hepatitis C virus-induced innate immune response through PCBP2.Journal of Virology, 91:23 e01264-17, 2017 (合作作者，影响因子：4.663，JCR一区)
Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst and Piet Maes. High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination, Journal of Virology, 89(15):7673–7695, 2015 (合作作者，影响因子: 4.7，JCR一区)
Linyun He, Mowei Tang, Ting Xiao, Hailan Liu, Wei Liu, Guangdi Li, Feng Zhang, Yalun Xiao, Zhiguang Zhou, Feng Liu1, Fang Hu. Obesity Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16-PGC-1α Transcriptional Network. Diabetes. 2018 Dec;67(12):2585-2600 (合作作者，影响因子：7.273， JCR一区)
Wen Meng, Xiuci Liang, Hongzhi Chen, Hairong Luo, Juli Bai, Guangdi Li, Qinghai Zhang, Ting Xiao, Sijia He, Yacheng Zhang, Zhipeng Xu, Bo Xiao, Fang Hu, and Feng Liu, Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway, Diabetes, 66(5):1196-1213, 2017 (合作作者，影响因子: 8.7，JCR一区)
Ahmed A Al-Qahtani, Mahmoud Reza Pourkarim, Nídia Sequeira Trovão, Valentijn Vergote, Guangdi Li, Marijn Thijssen, Ayman A Abdo, Faisal M Sanai, Damian Dela Cruz, Marie Fe F Bohol, Mashael R Al-Anazi, Mohammed N Al-Ahdal，Molecular epidemiology, phylogenetic analysis and genotype distribution of hepatitis B virus in Saudi Arabia: Predominance of genotype D1. Infect Genet Evol. 2020 Jan;77:104051. PMID: 31634640. doi: 10.1016/j.meegid.2019.104051 (合作作者，影响因子：2.773)
Andrea-Clemencia Pineda-Peña, Marta Pingarilho, Guangdi Li, Bram Vrancken, Pieter Libin, Perpétua Gomes, Ricardo Jorge Camacho, Kristof Theys, Ana Barroso Abecasis, Portuguese HIV-1 Resistance Study Group, Drivers of HIV-1 transmission: The Portuguese case. PLoS One. 2019;14(9):e0218226. (合作作者，影响因子：2.74)
Meizhu Liu, Lingxiang Wu, Weijing Wu, Guangdi Li, Taisheng Cai, Jiaxi Liu. The relationships among verbal ability, executive function, and theory of mind in young children with cochlear implants. International journal of audiology, 2018 Dec;57(12):875-882 (合作作者，影响因子：1.759， JCR高被引)
Li Tan, Le Bai, Ling Wang, Lagu He, Guangdi Li, Wenhan Du, Ting Shen, Zheyi Xiang, Jiali Wu, Zhonghua Liu, Min Hu. Antifungal activity of spider venom-derived peptide lycosin-I against Candida tropicalis. Microbiological Research. 2018 Nov;216:120-128. (合作作者，影响因子：2.777,JCR二区)
Zhuoying Liu, Ting Xiao, Guangdi Li, Fang Hu. APPL, More Than Just Adiponectin Receptor Binding Proteins. Cellular Signalling, 32:76-84, 2017 (合作作者，影响因子: 4.2,JCR一区)
Lize Cuypers, Francesca Ceccherini Silberstein, Kristel Van Laethem, Guangdi Li, Anne-Mieke Vandamme, Jürgen Kurt Rockstroh. Impact of HCV genotype on treatment regimens and drug resistance: a snapshot in time: HCV genotyping for treatment and drug resistance, Reviews in Medical Virology, Nov;26(6):408-434, 2016 (合作作者，影响因子: 4.5,JCR一区)
Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst and Piet Maes. High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination, Journal of Virology, 89(15):7673–7695, 2015 (合作作者，影响因子: 4.7)
Andrea-Clemencia Pineda, Nuno Rodrigues Faria, Francisco-Javier Diaz, Patricia Olaya, Casper Møller Frederiksen, Guangdi Li, Arley Gomez-Lopez, Philippe Lemey, Anne-Mieke Vandamme. Trends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic. PLOS One, PLoS ONE 01; 9(7):e101738, 2014 (合作作者，影响因子: 3.51)
Sarah Megens, Dolores Vaira, Greet De Baets, Nathalie Dekeersmaeker, Yoeri Schrooten, Guangdi Li, Joost Schymkowitz, Frederic Rousseau, Anne-Mieke Vandamme, Michel Moutschen, Kristel Van Laethem. Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits, Virology, 456:310–318, 2014 (合作作者，影响因子: 3.27)
Eline Boons, Guangdi Li, Els Vanstreels, Thomas Vercruysse, Christophe Pannecouque, Anne-Mieke Vandamme, Dirk Daelemans. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity. Antiviral Research, 12, 91-102, 2014 (合作作者，影响因子: 3.43)
七、指导本科生创新创业课题
本人作为第一指导老师，指导了本科生的老员工创新创业课题，情况如下：
（1）省级，项目名称：人类免疫缺陷病毒Gag基因突变诱导蛋白酶抑制剂耐药性的系统生物学研究，蒋怡珂, 苏璎珞, 谭钧元, 王立天, 李星，经费：8000元，时间：2023-2024
（2）省级，项目名称：基于ELES模型的新冠肺炎疫情下老员工消费结构的分析, 本科生成员：陶李, 曾诗琴, 傅兰乔, 黄涵宁, 朱湘郡，经费：10000元，时间：2020-2021
（3）省级，项目名称：疫情背景下老员工网课学习情况数据挖掘及对策分析, 本科生成员：陈昊章, 扎西普赤, 陈颖昕, 时顺一，经费：10000元，时间：2020-2021
（4）省级，项目名称：Meta分析探究呼吸系统疾病拭子自取样替代医务人员取样的可行性, 徐伟嘉, 罗涵, 叶升晖, 牟联明, 度皓元，经费：3000元，时间：2021-2022
（5）校级，项目名称：学术英语及留学交流平台—雅一英语，本科生成员：郑杰，郝婉蒙，熊哲，陈金玲，陈慧琳，经费：500元，时间：2023-2024
（6）校级，项目名称：基于时空维度的老员工新冠疫苗认知及接种意愿分析, 本科生成员：张溶, 刘美琳, 张倩倩, 田子悦, 马英萍，经费：1000元，时间：2021-2022
（7）校级，项目名称：后疫情时代家庭关系对老员工心理健康影响, 本科生成员：李梦婷, 黄幸垚,再努热·吾买尔,马金国，经费：500元，时间：2022-2023
八、著作
（1）《医学统计学》第五版-第41章R语言，人民卫生出版社，2020年
（2）《Encyclopedia of Virology, Fourth Edition》- Volume 4-Chapter 1: Antiviral Classification, 出版社: Academic Press, 2021年
（3）《Antiviral Discovery for Highly Pathogenic Emerging viruses》 Chapter 1: Overview of Antiviral Drug Discovery and Development，出版社：The Royal Society of Chemistry
九、专利和软著
1. 李广迪，黄洁，张盼，肖彪，李舶旗，刘颖，抗病毒药物综合信息管理系统V1.0，2023年，软著登字第12191868号
十、期刊副主编和审稿人
（1）副主编：《Journal of Medical Virology》影响因子12.7，《Viruses》影响因子4.7，《Scientific Reports》影响因子4.6分
（2）审稿人：《Journal of Medical Virology》，《Viruses》,《BMC Medicine》，《Science Advances》, 《Nature Communications》, 《Clinical infectious Diseases》, 《Journal of infection and public health》, 《Virology》等SCI期刊。
十一、博士生/研究生招生方向
欢迎优秀员工报考我的硕士和博士生，丰厚的助研津贴，推荐国外留学和交流机会。
